Founders often find themselves isolated and alone. You have to make multiple decisions all the time, because there are so many fires you need to put out on a daily basis , and you find it hard to keep your sanity. It's common to feel depressed - for example, when your star programmer leaves for a higher paying job; or your investor refuses to give you a bridge round; or your customers refuse to pay their bills. On some days, everything which can go wrong goes wrong, and you feel the the whole world is conspiring against you.